Newest Articles
- Combining sophisticated fast FLIM, confocal microscopy, and STED nanoscopy for live-cell imaging of tunneling nanotubes
Here, we proposed an innovative advanced light imaging to reveal the dynamics of tunneling nanotubes (TNTs) that are now considered as a long- and short-distance route for cell-to-cell communication.
- Porphyrin overdrive rewires cancer cell metabolism
Cancer cells exhibit a metabolic phenotype termed “porphyrin overdrive,” characterized by dysregulated heme metabolic pathways for intermediate accumulation. This rewiring is cancer-essential and cancer-specific. Targeting this vulnerability with a “bait-and-kill” strategy shows promise in eradicating malignant cells.
- lncRNA LINC00941 modulates MTA2/NuRD occupancy to suppress premature human epidermal differentiation
The long non-coding RNA LINC00941 regulates skin differentiation through recruitment of the epigenetic regulator complex NuRD.
- Subdomains of the Helicobacter pylori Cag T4SS outer membrane core complex exhibit structural independence
Structural and proteomic analyses of H. pylori Cag T4SSs purified from deletion mutants highlight the unexpected structural independence between the OMC and PR, two major subdomains of this complex.
- Frataxin deficiency shifts metabolism to promote reactive microglia via glucose catabolism
Frataxin depletion triggers reactive microglia with increase glucose catabolism. Butyrate treatment reinstates immunometabolic balance, potentially offering neuroprotection.
- Autocrine VEGF drives neural stem cell proximity to the adult hippocampus vascular niche
Autocrine VEGF signaling is necessary to maintain adult neural stem and progenitor cell proximity to blood vessels in the adult hippocampus and promotes their motility or adhesion.