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SGC Spotlight

The women leading open science advancements at the Structural Genomics Consortium stress some of the challenges faced by women in academia, the role of mentorship, and the proactive steps SGC takes to empower women in the field.

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Latest Structures

CBLB: Human E3 ubiquitin-protein ligase CBL-B, TKB domain, in complex with N-Aryl isoindolin-1-one
SETDB1: Human histone-lysine N-methyltransferase SETDB1, triple Tudor domain, in complex with compound UNC6535
CARM1: Human protein arginine methyltransferase CARM1, methyltransferase domain, in complex with compound YD1290
PRMT3: Human protein arginine N-methyltransferase 3, methyltransferase domain, in complex with compound II710
DCAF1: Human DDB1- and CUL4-associated factor 1, WDR domain, in complex with small molecule OICR-8268
53BP1: Human TP53 binding protein tandem Tudor domain in complex with MFP-5956
53BP1: Human TP53 binding protein, tandem Tudor domain, in complex with compound MFP-5973
pfPKG: Plasmodium falciparum cGMP-dependent protein kinase PKG in complex with RY-1-165
EIF2A: Human eukaryotic translation initiation factor 2A, WDR domain
all structures

New Publications

The identification of high-preforming antibodies for Ubiquilin-2 for use in Western Blot, immunoprecipitation, and immunofluorescence.
F1000Res
Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.
PLoS One
A guide to selecting high-performing antibodies for Rab1A and Rab1B for use in Western Blot, immunoprecipitation and immunofluorescence.
F1000Res
Identification of high-performing antibodies for Moesin for use in Western Blot, immunoprecipitation, and immunofluorescence.
F1000Res
Identification of high-performing antibodies for Superoxide dismutase [Cu-Zn] 1 (SOD1) for use in Western blot, immunoprecipitation, and immunofluorescence.
F1000Res
The identification of high-performing antibodies for Coiled-coil-helix-coiled-coil-helix domain containing protein 10 (CHCHD10) for use in Western Blot, immunoprecipitation and immunofluorescence.
F1000Res
Identification of high-performing antibodies for Vacuolar protein sorting-associated protein 35 (hVPS35) for use in Western Blot, immunoprecipitation and immunofluorescence.
F1000Res
full list

Chemical Probes

UNC8732 - A degrader-based chemical probe for NSD2.
28th January 2024
OICR11029 - A chemical probe for BCL6.
28th January 2024
PFI-8 - A (pan) chemical probe for the YEATS family.
28th January 2024
JA310 - A chemical probe for MST3 and MST4.
5th November 2023
show all

News from SGC

Bridging the Gap Between Leukemia Research and Real-Life Impact
Posted on 4th April 2024
Structural Genomics Consortium at the University of Toronto Welcomes Hui Peng
Posted on 27th March 2024
Structural Genomics Consortium Principal Investigators Receive $4.3 Million Infrastructure Award to Transform Early Drug Discovery at the University of Toronto
Posted on 14th March 2024
Insights and Lessons Learned: Highlights from the CACHE Symposium
Posted on 12th March 2024
Shaping Tomorrow: The Women Leading Open Science Advancements at the Structural Genomics Consortium [Part 2]
Posted on 7th March 2024
more news
 

SGC Careers

Open vacancies : 2
Postdoctoral Fellow in Computational Chemistry
Postdoctoral Fellow in Cell and Molecular Biology
SGC Careers page
 
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